It appears that in 2003 Drupal there was a MS SQL option for Drupal, but the current INSTALL.txt only mentions MySQL and PostgreSQL.
I have run Drupal on my Windows laptop (WinXP Home), using Apache and MySQL, but I've never tried Windows 2003 and IIS. Of course, this was in 'hacking' mode, not full-blown production mode.
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Drupal4libcamp
February 27, 2009, Darien Public Library, Darien, CT
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No IIS/SQL Server support apparent
It appears that in 2003 Drupal there was a MS SQL option for Drupal, but the current INSTALL.txt only mentions MySQL and PostgreSQL.
I have run Drupal on my Windows laptop (WinXP Home), using Apache and MySQL, but I've never tried Windows 2003 and IIS. Of course, this was in 'hacking' mode, not full-blown production mode.